急性骨髄性白血病: 良い亜型、悪い亜型、最悪な亜型

[title]
Acute Myeloid Leukemia: The Good, the Bad, and the Ugly.

[author]
Kuykendall A, et al. Am Soc Clin Oncol Educ Book. 2018.

[Abstract]
Acute myeloid leukemia (AML) was initially subdivided according to morphology (the French-American-British system), which proved helpful in pathologic categorization. Subsequently, clinical and genomic factors were found to correlate with response to chemotherapy and with overall survival. These included a history of antecedent hematologic disease, a history of chemotherapy or radiation therapy, the presence of various recurrent cytogenetic abnormalities, and, more recently, the presence of specific point mutations. This article reviews the biology and responses of one AML subgroup with consistent response and good outcomes following chemotherapy (core-binding factor leukemia), and two subgroups with persistently bad, and even ugly, outcomes (secondary AML and TP53-mutated AML).

[memo]
◼︎知らない
subdivide :細分化する
morphology :形態学
Subsequently :その後に
antecedent :先行する、先立つ
hematologic :血液学的な

◼︎使いたい
which proved helpful in pathologic categorization
were found to correlate with response to chemotherapy